Science/Tech
Researchers discover gene that permanently stops cancer cell proliferation
“We have identified a new direction for cancer therapy and the new direction is leading us to a reduction in toxicity in cancer therapy, compared with chemotherapy or radiation therapy,” said Dr. Zhang, assistant professor, Department of Pharmacology at the School of Medicine, and member of the university’s Case Comprehensive Cancer Center.
“With this discovery, scientists could stop the proliferation of cancer cells, allowing physicians time to fix cells and genetic errors.” While studying the basic mechanisms for genome integrity, Dr. Zhang’s team unexpectedly discovered an active mutant form of human Chk1, which is also a non-natural form of this gene. This mutation changed the protein conformation of Chk1 from the inactive form into an active form. Remarkably, the research team discovered that when expressed in cancer cells, this active mutant form of Chk1 permanently stopped cancer cell proliferation and caused cell death in petri dishes even without the addition of any chemotherapeutic drugs.
The biggest advantage of this potential strategy is that no toxic chemotherapeutic drug is needed to achieve the same cancer killing effect used with a combination of Chk1 inhibitors and chemotherapeutic drugs. Cells respond to DNA damage by activating networks of signaling pathways, termed cell cycle checkpoints. Central to these genome pathways is the protein kinase, called Chk1. Chk1 facilitates cell survival, including cancer cells, under stressful conditions, such as those induced by chemotherapeutic agents, by placing a temporary stop on the cell cycle progression and coordinating repair programs to fix the DNA errors.
It has long been suggested that combining Chk1 inhibition with chemotherapy or radiotherapy should significantly enhance the anticancer effect of these therapies. This idea has serves as the basis for multiple pharmaceutical companies searching for potential Chk1 inhibitors that can effectively combine with chemotherapy in cancer therapy. To date, no Chk1 inhibitor has passed the clinical trial stage III .
This led Dr. Zhang’s team to look for alternative strategies for targeting Chk1 in cancer therapy. Future research by Dr. Zhang and his team will consider two possible approaches to artificially activating Chk1 in cancer cells. One possibility is to use the gene therapy concept to deliver the active mutant form of Chk1 that the team discovered, into cancer cells.
The other is to search for small molecules that can induce the same conformational change of Chk1, so that they can be delivered into cancer cells to activate Chk1 molecules. The consequence of either would be permanent cell proliferation inhibition and cancer.
Provided by Case Western Reserve University
Read Full Post | Make a Comment ( None so far )Students Having Heart Attacks from WiFi
The Microwave Factor
Microwave – and other forms of electromagnetic – radiation are major (but conveniently disregarded, ignored, and overlooked) factors in many modern unexplained disease states. Insomnia, anxiety, vision problems, swollen lymph, headaches, extreme thirst, night sweats, fatigue, memory and concentration problems, muscle pain, weakened immunity, allergies, heart problems, and intestinal disturbances are all symptoms found in a disease process originally described in the 1970s as Microwave Sickness.
Defibrillators In High Schools??
If your child (or you!) has been getting unexplained headaches, nosebleeds, insomnia, heart palpitations, nausea or dizziness, then it’s a really good idea for you to take a look at your cell phone and WiFi exposure as a possible cause. This email sent out by a woman working tirelessly to get her school to hardwire their computers is a very powerful testimony and may do more to make people aware of the ill health effects of this technology than all the scientific info I’ve been posting here:My experience is different than most parents.Last month my internet provider died of Adenoid Cystic Carcinoma at 48 leaving behind 4 young kids. He used his cellular phone much more than 30 minutes a day and used wifi routers at his office and at home as well.
A few weeks ago singer Adam Yauch died of Parotid Salivary Gland cancer at 47. He also used a cellular phone heavily for more than 20 years.
It’s possible that both deaths were preventable.
I have a friend who is a chef and another who has a 16 year old daughter. Both live with wifi routers and use wifi enabled laptops and use their cellular phones more than 30 minutes a day and sleep with their cell phones on their night table. Both women stopped menstruating for seven to ten months until they reduced their wireless usage.
My friend’s son has heart palpitations at the age of 12 and needs a heart monitor and his school has several commercial grade multiple antenna wifi routers. When he is at home, his heart has a regular rhythm.
My naturopath’s daughter sat under a commercial grade multiple antenna wifi router at school for a year and became dizzy, nauseas, anxious, had ringing ears, headaches, and was light headed – which are all classic symptoms of over exposure to microwave radiation – that they had to home school her and ultimately move to a remote location away from multiple forms of microwave radiofrequency radiation.
The Toronto school board now has defibrillators in every high school because of the risk of heart attack for students.
Is it just me or does it seem extremely odd that teenagers are having heart attacks regularly?
I question everything.
These deaths and illnesses make me wonder what are we actually allowing when we say yes to a class 2b carcinogen that can’t be touched, seen, heard, smelled or tasted in our children’s schools?
I implore you to consider maintaining the current wired internet access at one school of each level in each district as you reflect on: “Who is liable when children start getting over exposed from microwave wireless radiation – a class 2b carcinogen?”
The schools are taking that liability away from wifi manufacturers.
Do all schools have the liability insurance to cover the illnesses that will happen in the coming years or even in 10, 20, or 30 years?
Why won’t insurance companies cover wifi manufacturers?
With the best actuarial studies – it is due “to the incalculable risk to human health.”
When parents start sending in their Notices of Liability to school administrators, school trustees and school district officials, will schools start treating Microwave Wireless Radiation as the class 2b carcinogen it is and protect all children with the precautionary principle and maintain current wired internet access and think: Safety over Convenience?
Microwave Wireless Radiation ultimately affects everyone.
-Susan McFee
Langley Fine Arts School PAC SD #35″
My own kids are so concerned about this that they set up their own website to educate other kids, they called it: RadiationEducation.com
If you’re a parent, go to their site and download their free Action Pack. I also have numerous posts on this site going into detail about the health effects of microwave radiation from WiFi computers, cell phones, iPads, Wii, X-box, etc. Just type “WiFi Radiation” into my SEARCH box on this site and it will pull all my posts up for you.
Charlie Teo is one of the few neurosurgeon’s who is willing to stand up and say anything about cell phones causing brain tumours, so definitely check him out.
http://www.listen2yourgut.com/blog/defibrillators-in-high-schools/
Ballpoint Pens Do Not Work in Zero Gravity
When NASA first started sending up astronauts, they quickly discovered that ballpoint pens would not work in zero gravity. To combat the problem, NASA scientists spent a decade and $12 billion to develop a pen that writes in zero gravity, upside down, underwater, on almost any surface including glass and at temperatures ranging from below freezing to 300 C.
The Russians used a pencil.
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